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血清CA199、CEA及AFP联合检测对胃癌的诊断效能观察

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目的 分析血清糖类抗原199(CA199)、癌胚抗原(CEA)及甲胎蛋白(AFP)联合检测对胃癌的诊断效能.方法 选取我院2021年1月至2022年12月收治的疑似胃癌患者116例,检测其血清CA199、CEA及AFP,分析血清CA199、CEA及AFP联合检测对胃癌的诊断效能.结果 组织病理学检查结果显示,116例患者中胃癌67例,慢性胃炎33例,胃溃疡16例.血清CA199、CEA、AFP联合检测准确度、灵敏度及阴性预测值均高于血清CA199、CEA、AFP单独检测(P<0.05).κ 一致性检验提示血清CA199、CEA、AFP联合检测对胃癌的诊断具有极好的一致性(κ=0.803,P<0.05).结论 血清CA199、CEA及AFP联合检测对胃癌具有较高的诊断效能.
Observation on the Diagnostic Efficacy of Combined Detection of Serum CA199,CEA and AFP in Gastric Cancer
Objective To analyze the diagnostic efficacy of combined detection of serum carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),and alpha fetoprotein(AFP)in gastric cancer.Methods 116 suspected gastric cancer patients admitted to our hospital from January 2021 to December 2022 were selected,and the serum CA199,CEA and AFP were detected.The diagnostic efficacy of combined detection of serum CA199,CEA and AFP for gastric cancer was analyzed.Results The histopathological examination results showed that 67 cases of gastric cancer,33 cases of chronic gastritis,and 16 cases of gastric ulcers among 116 patients.The accuracy,sensitivity,and negative predictive value of combined detection of serum CA199,CEA and AFP were higher than those of single detection of serum CA199,CEA,and AFP(P<0.05).κ consistency test suggested that the combined detection of serum CA199,CEA and AFP had excellent consistency in the diagnosis of gastric cancer(κ=0.803,P<0.05).Conclusions The combined detection of serum CA199,CEA and AFP has higher diagnostic efficacy for gastric cancer.

Serum carbohydrate antigen CA199Carcinoembryonic antigenAlpha fetoprotein

雷云飞、郜俪薇、张婷

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河南科技大学第二附属医院医学检验科,河南洛阳 471000

血清糖类抗原CA199 癌胚抗原 甲胎蛋白

2024

临床医学工程
国家医疗保健器具工程技术研究中心

临床医学工程

影响因子:0.193
ISSN:1674-4659
年,卷(期):2024.31(9)