Expression and Clinical Significance of Human Herpesvirus 6 and Human Papillomavirus in Patients with Cervical Cancer
Objective To explore the expression and clinical significance of human herpesvirus type 6(HHV-6)and human papillomavirus(HPV)in patients with cervical cancer.Methods 86 patients with suspected cervical cancer were selected,and HHV-6 and HPV expressions were detected.Taking colposcopy pathological biopsy results as the gold standard,the consistency of HPV-DNA and HHV-6 DNA tests in the diagnosis of cervical cancer was analyzed.The diagnostic efficiency of HPV-DNA and HHV-6 DNA tests for cervical cancer was compared.Results 71 cases of 86 suspected cervical cancer patients were confirmed by colposcopy pathological biopsy.κ test analysis results showed that HPV-DNA and HHV-6 DNA in the diagnosis of cervical cancer had high consistency with colposcopy pathological biopsy results(P＜0.05).No statistical difference was found in the sensitivity(91.55％vs.88.73％),specificity(86.67％vs.80.00％)and accuracy(90.70％vs.87.21％)between HPV-DNA and HHV-6 DNA tests in the diagnosis of cervical cancer(P＞0.05).Conclusions HHV-6 and HPV are mostly positive expressions in cervical tissues of cervical cancer patients.HHV-6 and HPV tests in cervical cancer patients can improve the accuracy of disease screening.
Human herpesvirus type 6Human papillomavirusCervical cancerDisease screening
国家科技期刊平台
NSTL
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