不同剂量瑞马唑仑在髋关节置换术中的镇静效果比较研究
Comparative Study on Sedation Effect of Different Doses of Remimazolam during Hip Arthroplasty
徐惠平 1余晓磊 1许倩1
作者信息
- 1. 灵宝市中医院手术麻醉科,河南三门峡 472500
- 折叠
摘要
目的 比较不同剂量瑞马唑仑在髋关节置换术中的镇静效果.方法 选择我院收治的72例髋关节置换术患者,随机分为A组与B组各36例.两组均行腰硬联合麻醉,A组持续泵注瑞马唑仑3μg·kg-1·min-1,B组持续泵注瑞马唑仑4μg·kg-1·min-1.比较两组围术期指标、镇静效果、不良反应情况.结果 A组术后睁眼时间、拔管时间、定向力恢复时间明显短于B组(P＜0.05).镇静后5 min、15 min、30 min、60 min,两组的BIS值明显低于阻滞前、平面固定后(P＜0.05);镇静后15 min,A组BIS值明显高于B组(P＜0.05).A组不良反应发生率明显低于B组(P＜0.05).结论 与术中泵注4 μg·kg-1·min-1相比,髋关节置换术中泵注瑞马唑仑3μg·kg-1·min-1具有良好的镇静效果,且麻醉恢复时间短,安全性更高.
Abstract
Objective To xompare the sedation effect of different doses of remimazolam during hip arthroplasty.Methods 72 patients undergoing hip arthroplasty in our hospital were selected and randomly divided into group A and group B,with 36 cases in each group.Both groups were given combined spinal epidural anesthesia.Group A was given continuous infusion of 3 μg kg-1·min-1 of remimazolam,and group B was given continuous infusion of 4 μg·kg1·min1 of remimazolam.The perioperative indicators,sedation effect and adverse reactions were compared between the two groups.Results The eye opening time,extubation time and orientation recovery time of group A were significantly shorter than those of group B(P＜0.05).5 min,15 min,30 min and 60 min after sedation,the BIS values of the two groups were significantly lower than those before block and after plane fixation(P＜0.05).15 min after sedation,the BIS value of group A was significantly higher than that of group B(P＜0.05).The incidence of adverse reactions of group A was significantly lower than that of group B(P＜0.05).Conclusions Compared with intraoperative infusion of 4 μg·kg-1·min-1,infusion of 3 μg·kg1·min-1 of remimazolam has good sedation effect,short recovery time and higher safety.
关键词
髋关节置换术/瑞马唑仑/不同剂量/镇静效果/安全性Key words
Hip arthroplasty/Remimazolam/Different doses/Sedation effect/Safety引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据