Effect of Dienogest Combined with Goserelin in the Treatment of Endometriosis and the Impact on VEGF and CA125 Levels
Objective To explore the effect of dienogest combined with goserelin in the treatment of endometriosis and the impact on VEGF and CA125 levels.Methods 100 patients with endometriosis admitted to our hospital from January 2020 to January 2023 were randomly divided into two groups,with 50 cases in each group.The control group was treated with dienogest,while the observation group was treated with dienogest combined with goserelin.The clinical efficacy,vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),and adverse reactions were compared between two groups.Results The total effective rate of treatment in the observation group was 92.0％,higher than 76.0％in the control group(P＜0.05).After treatment,the VEGF and CA125 levels of the two groups decreased,and the VEGF and CA125 levels of the observation group were lower than those of the control group(P＜0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions Dienogest combined with goserelin in the treatment of patients with endometriosis can improve the clinical efficacy with high safety,and the mechanism may be related to the decrease of VEGF and CA125 levels.
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