Analysis on Correlation between HR-HPV Load and Postoperative Recurrence in Patients with High-Grade Squamous Intraepithelial Lesion
Objective To analyze the correlation between high-risk human papillomavirus(HR-HPV)load and postoperative recurrence in patients with high-grade squamous intraepithelial lesion(HSIL).Methods 80 HSIL patients undergoing cervical conization in our hospital from January 2021 to May 2022 were selected,and the HR-HPV load was detected at admission.Following up for 12 months after surgery,and postoperative recurrence was counted and grouped.The baseline data of the recurrence group and non-recurrence group were compared,and the correlation between HR-HPV load and postoperative recurrence in HSIL patients was analyzed.Results Among 80 HSIL patients,18 cases had postoperative recurrence,accounting for 22.50％.No statistical difference was found in the age,gravidity,parity,abortion history,surgical margin,pathological type and TCT test results between the recurrence group and the non-recurrent group(P＞0.05),but the HR-HPV load at admission in the recurrence group was higher than that in the non-recurrent group(P＜0.05).Logistic regression analysis showed that the abnormal over-expression of HR-HPV load at admission was the risk factor for postoperative recurrence in HSIL patients(OR＞1,P＜0.05).Conclusions The preoperative HR-HPV load of HSIL patients is correlated with postoperative recurrence,which may be a high risk factor for recurrence.
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