HR-HPV载量与高级别鳞状上皮内病变患者术后复发的相关性分析
Analysis on Correlation between HR-HPV Load and Postoperative Recurrence in Patients with High-Grade Squamous Intraepithelial Lesion
郭喆 1尚国栋1
作者信息
- 1. 河南科技大学第二附属医院检验科,河南洛阳 471000
- 折叠
摘要
目的 分析高危型人乳头瘤病毒(HR-HPV)载量与高级别鳞状上皮内病变(HSIL)患者术后复发的相关性.方法 选取2021年1月至2022年5月在我院行宫颈锥切手术治疗的80例HSIL患者,入院时检测其HR-HPV载量,术后随访12个月,统计患者术后复发情况并进行分组,比较复发组和未复发组的基线资料,分析HR-HPV载量与HSIL患者术后复发的相关性.结果 80例HSIL患者术后复发18例,占比22.50％;复发组与未复发组的年龄、孕次、产次、流产史、切缘情况、病理类型、TCT检测结果比较无统计学差异(P＞0.05);复发组入院时的HR-HPV载量高于未复发组(P＜0.05).Logistic回归分析结果显示,HSIL患者入院时的HR-HPV载量异常过表达是其术后复发的危险因素(OR＞1,P＜0.05).结论 HSIL患者术前HR-HPV载量与其术后复发有一定相关性,可能是复发高风险因子.
Abstract
Objective To analyze the correlation between high-risk human papillomavirus(HR-HPV)load and postoperative recurrence in patients with high-grade squamous intraepithelial lesion(HSIL).Methods 80 HSIL patients undergoing cervical conization in our hospital from January 2021 to May 2022 were selected,and the HR-HPV load was detected at admission.Following up for 12 months after surgery,and postoperative recurrence was counted and grouped.The baseline data of the recurrence group and non-recurrence group were compared,and the correlation between HR-HPV load and postoperative recurrence in HSIL patients was analyzed.Results Among 80 HSIL patients,18 cases had postoperative recurrence,accounting for 22.50％.No statistical difference was found in the age,gravidity,parity,abortion history,surgical margin,pathological type and TCT test results between the recurrence group and the non-recurrent group(P＞0.05),but the HR-HPV load at admission in the recurrence group was higher than that in the non-recurrent group(P＜0.05).Logistic regression analysis showed that the abnormal over-expression of HR-HPV load at admission was the risk factor for postoperative recurrence in HSIL patients(OR＞1,P＜0.05).Conclusions The preoperative HR-HPV load of HSIL patients is correlated with postoperative recurrence,which may be a high risk factor for recurrence.
关键词
高级别鳞状上皮内病变/HR-HPV载量/宫颈锥切手术/复发/相关性Key words
High-grade squamous intraepithelial lesion/HR-HPV load/Cervical conization/Recurrence/Correlation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据