替吉奥联合奥沙利铂对中晚期胃癌患者的治疗效果
Therapeutic Effect of Tegafur Combined with Oxaliplatin on Patients with Middle-Advanced Gastric Carcinoma
曹静 1郭玉霞 2王秀娟3
作者信息
- 1. 驻马店市第一人民医院肿瘤放疗科,河南驻马店 463000
- 2. 驻马店市第一人民医院肿瘤内科,河南驻马店 463000
- 3. 驻马店市第一人民医院介入科,河南驻马店 463000
- 折叠
摘要
目的 探讨替吉奥联合奥沙利铂治疗中晚期胃癌(GC)患者的临床效果.方法 选取2019年8月至2020年8月我院收治的中晚期GC患者65例,根据治疗方法的不同分为A组(32例)和B组(33例).A组接受替吉奥联合奥沙利铂治疗,B组接受卡培他滨联合奥沙利铂治疗.比较两组的临床疗效,胃泌素(GAS)及survivin抗体水平,以及毒副反应.结果 A组的治疗总有效率为68.75％,高于B组的42.42％(P＜0.05).治疗4个周期后,A组的血清GAS及 survivin抗体水平均低于B组(P＜0.05).A组的恶心呕吐、脱发、肝肾损伤、白细胞减少发生率与B组比较,差异无统计学意义(P＞0.05).结论 替吉奥联合奥沙利铂治疗中晚期GC患者的效果确切,可明显降低患者的血清GAS及survivin抗体水平,且未明显增加毒副反应发生风险.
Abstract
Objective To explore the clinical effect of tegafur combined with oxaliplatin in the treatment of patients with middle-advanced gastric carcinoma(GC).Methods A total of 65 patients with middle-advanced GC admitted to our hospital from August 2019 to August 2020 were selected and divided into group A(32 cases)and group B(33 cases)according to different treatment methods.Group A was treated with tegafur combined with oxaliplatin,and group B was treated with capecitabine combined with oxaliplatin.The clinical efficacy,gastrin(GAS)and survivin antibody levels,and toxic side effects were compared between the two groups.Results The total effective rate of treatment in group A was 68.75％,higher than 42.42％in group B(P＜0.05).After 4 cycles of treatment,the levels of serum GAS and survivin antibody in group A were lower than those in group B(P＜0.05).No significant difference was found in the incidences of nausea and vomiting,alopecia,liver and kidney injury,and leukopenia between group A and group B(P＞0.05).Conclusions Tegafur combined with oxaliplatin in the treatment of patients with middle-advanced GC has exact effect,which can obviously reduce the serum GAS and survivin antibody levels of patients,and does not significantly increase the occurrence risk of toxic side effects.
关键词
中晚期胃癌/替吉奥/奥沙利铂/胃泌素/survivin抗体Key words
Middle-advanced gastric carcinoma/Tegafur/Oxaliplatin/Gastrin/survivin antibody引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据