摘要
目的 探讨分析支原体肺炎(MP)患者血清补体C3、C反应蛋白(CRP)、免疫球蛋白水平的变化以及临床意义.方法 选取120例MP患者为观察组,60例健康体检者为对照组,比较两组的血清补体C3、CRP、IgA、IgG、IgM水平.比较观察组中不同病情严重程度患者的血清补体C3、CRP、IgA、IgG、IgM水平,分析以上指标与MP患者病情严重程度的相关性.结果 观察组的血清补体C3、CRP、IgG、IgM水平均高于对照组,IgA水平低于对照组(P＜0.05).观察组中重症患者的血清补体C3、CRP、IgG、IgM水平高于轻症患者,IgA水平低于轻症患者(P＜0.05).Spearman相关性分析显示,血清补体C3、CRP、IgG、IgM水平与MP患者病情严重程度呈明显正相关,血清IgA水平呈明显负相关(P＜0.05).结论 MP患者的血清补体C3、CRP、IgA、IgG、IgM水平呈异常表达,血清补体C3、CRP、IgA、IgG、IgM水平与MP患者病情严重程度密切相关.
Abstract
Objective To explore and analyze the changes and clinical significance of serum complement C3,C-reactive protein(CRP)and immunoglobulin levels in patients with mycoplasmal pneumonia(MP).Methods 120 patients with MP were selected as the observation group,60 healthy subjects were selected as the control group,and the levels of serum complement C3,CRP,IgA,IgG and IgM were compared between the two groups.The levels of serum complement C3,CRP,IgA,IgG and IgM in patients with different disease severity in the observation group were compared,and the correlations between the above indexes and the disease severity of MP patients were analyzed.Results The levels of serum complement C3,CRP,IgG and IgM in the observation group were higher than those in the control group,and the level of IgA was lower than that in the control group(P＜0.05).In the observation group,the levels of serum complement C3,CRP,IgG and IgM in severe patients were higher than those in mild patients,and the level of IgA was lower than that in mild patients(P＜0.05).Spearman correlation analysis showed that serum complement C3,CRP,IgG,IgM levels were significantly positively correlated with the disease severity of MP patients,and serum IgA level was significantly negatively correlated with the disease severity of MP patients(P＜0.05).Conclusions The levels of serum complement C3,CRP,IgA,IgG and IgM in MP patients show abnormal expression.The levels of serum complement C3,CRP,IgA,IgG and IgM are closely related to the disease severity of MP patients.
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