Effects and Safety of Different Doses of rhBNP in Emergency PCI for the Treatment of Acute Myocardial Infarction
Objective To analyze the effects and safety of different doses of rhBNP in emergency percutaneous coronary intervention(PCI)for the treatment of acute myocardial infarction.Methods 64 patients with acute myocardial infarction were randomly divided into two groups.During emergency PCI treatment,group A was given 0.01 µg·kg-1·min-1 rhBNP,and group B was given 0.015 μg·kg-1·min-1 rhBNP for 24 h continuously.The therapeutic effect,vascular endothelial function and adverse reactions were compared between the two groups.Results No significant difference was found in the total effective rate and incidence of adverse reactions between the two groups(P＞0.05).After treatment,ET-1 in group B was significantly lower than that in group A,and NO was significantly higher than that in group A(P＜0.05).Conclusions High-dose rhBNP can obviously improve the clinical symptoms of patients with acute myocardial infarction treated by emergency PCI,and improve their vascular endothelial function,without increase of medication risk.
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