外周血MPV、PLR、NLR对晚期结肠癌患者预后的预测价值
Predictive Value of MPV,PLR and NLR in Peripheral Blood for the Prognosis of Patients with Advanced Colon Cancer
贾梦荻 1袁雯 1张肇铱1
作者信息
- 1. 河南科技大学第一附属医院肿瘤内科一病区,河南洛阳 471000
- 折叠
摘要
目的 探讨外周血平均血小板体积(MPV)、血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)对晚期结肠癌(CC)患者预后的预测价值.方法 选取2018年10月至2021年10月我院收治的68例行CapeOX化疗方案治疗的晚期CC患者,根据化疗后1年的预后情况分为死亡组(n=23)和存活组(n=45),对比两组化疗前的外周血MPV、PLR、NLR,分析外周血MPV、PLR、NLR对晚期CC患者预后的预测价值.结果 死亡组的外周血MPV、PLR、NLR均显著高于存活组(P＜0.05).ROC曲线显示,外周血MPV、PLR、NLR联合预测晚期CC患者预后的A UC为0.879,显著高于三者单独预测(P＜0.05).结论 外周血MPV、PLR、NLR联合预测晚期CC患者预后的价值较高.
Abstract
Objective To explore the predictive value of mean platelet volume(MPV),platelet-to-lymphocyte ratio(PLR)and neutrophil-to-lymphocyte ratio(NLR)in peripheral blood for the prognosis of patients with advanced colon cancer(CC).Methods A total of 68 patients with advanced CC treated with CapeOX chemotherapy regimen in our hospital from October 2018 to October 2021 were selected and divided into the death group(n=23)and the survival group(n=45)according to the prognosis at 1 year after chemotherapy.The MPV,PLR and NLR in peripheral blood before chemotherapy were compared between the two groups,and the predictive value of MPV,PLR and NLR in peripheral blood for the prognosis of patients with advanced CC was analyzed.Results The MPV,PLR and NLR in peripheral blood of the death group were significantly higher than those of the survival group(P＜0.05).ROC curve showed that the A UC of combined prediction of peripheral blood MPV,PLR and NLR for the prognosis of patients with advanced CC was 0.879,significantly higher than that of single prediction of three indicators(P＜0.05).Conclusions The combined prediction of peripheral blood MPV,PLR and NLR for the prognosis of patients with advanced CC has high value.
关键词
外周血/平均血小板体积/血小板与淋巴细胞比值/中性粒细胞与淋巴细胞比值/晚期结肠癌/预后/预测价值Key words
Peripheral blood/Mean platelet volume/Platelet-to-lymphocyte ratio/Neutrophil-to-lymphocyte ratio/Advanced colon cancer/Prognosis/Predictive value引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据