Distribution Characteristics of VAP Pathogens in Children with Mechanical Ventilation and the Value of Inflammatory Factor Monitoring
Objective To explore the distribution characteristics of ventilator-associated pneumonia(VAP)pathogens in children with mechanical ventilation and the value of inflammatory factor monitoring.Methods According to the occurrence of VAP,270 children with mechanical ventilation were divided into VAP group and non-VAP group,and the levels of inflammatory factors were compared between the two groups.The detection of pathogenic bacteria in children with VAP was recorded,and the distribution and drug resistance rate of pathogenic bacteria were analyzed.Results A total of 205 strains of pathogenic bacteria were isolated from 172 children with VAP,including 144 strains of gram-negative bacteria,57 strains of gram-positive bacteria and 4 strains of fungi.Both Klebsiella pneumoniae and Pseudomonas aeruginosa had the highest resistance rates to gentamicin,and had higher sensitivity to imipenem and meropenem.The levels of PCT,CRP,IL-6,IL-10 and TNF-α in VAP group were higher than those in non-VAP group(P＜0.05).Conclusions Gram-negative bacteria are the main infection pathogens of VAP in children with mechanical ventilation.Sensitive drugs to gram-negative bacteria can be used for early clinical treatment.Monitoring the expressions of inflammatory factors is helpful to predict the occurrence of VAP in the early stage.
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