Expression Differences and Clinical Significance of Serum NPSR1 and MTL in Patients with Different Subtypes of Function-al Dyspepsia
Objective To explore the expressions and clinical significance of serum neuropeptide S receptor 1(NPSR1)and motilin(MTL)in patients with different subtypes of functional dyspepsia.Methods 80 patients with functional dyspepsia were divided into EPS group(26 cases),PDS group(31 cases)and PDS overlapping EPS group(23 cases)according to different subtypes,and 30 healthy subjects were selected as the control group.The levels of serum NPSR1 and MTL in the four groups were compared,and the diagnostic efficacy of single and combined detection of serum NPSR1 and MTL was analyzed.Results The levels of serum NPSR1 in PDS overlapping EPS group,EPS group,PDS group and control group increased in turn,and the levels of serum MTL in PDS overlapping EPS group,PDS group,EPS group and control group increased in turn(P<0.05).ROC curve showed that the AUC of combined detection of serum NPSR1 and MTL in the diagnosis of functional dyspepsia was 0.932,higher than that of each index alone.Conclusions The expressions of serum NPSR1 and MTL in patients with different subtypes of functional dyspepsia are significantly different.The combined detection of serum NPSR1 and MTL has high efficiency in the diagnosis of functional dyspepsia.
SubtypeFunctional dyspepsiaNeuropeptide S receptor 1Motilin
国家科技期刊平台
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