Impact of Salmeterol Fluticasone Combined with Tiotropium Bromide on Serum Inflammatory Factors and Lung Function of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To explore the impact of salmeterol fluticasone combined with tiotropium bromide on serum inflammatory factors and lung function of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 96 patients with AECOPD admitted to our hospital from January 2020 to December 2022 were selected and randomly divided into two groups,with 48 cases in each group.The control group was treated with tiotropium bromide inhalation powder,and the observation group was treated with salmeterol fluticasone inhalation powder on the basis of the control group.The levels of serum inflammatory factors and lung function were compared between the two groups.Results After treatment,the levels of IL-6 and CRP in the two groups were significantly lower than those before treatment,and FEV1,PEF and FVC were significantly higher than those before treatment(P<0.05);The levels of IL-6 and CRP in the observation group were significantly lower than those in the control group,and FEV1,PEF and FVC were significantly higher than those in the control group(P<0.05).Conclusions Salmeterol fluticasone combined with tiotropium bromide in the treatment of patients with AECOPD can obviously relieve their inflammatory response and improve their lung function.
Acute exacerbation of chronic obstructive pulmonary diseaseSalmeterol fluticasoneTiotropium bromideInflammato-ry factorLung function
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