依折麦布联合奥扎格雷钠对进展性缺血性脑卒中患者神经功能及血管内皮功能的影响
Impact of Ezetimibe Combined with Ozagrel Sodium on Neurological Function and Vascular Endothelial Function of Patients with Progressive Ischemic Stroke
王苗苗 1薛文俊 1高延伦 1冯校迅1
作者信息
- 1. 平顶山市第一人民医院神经内科二病区,河南 平顶山 467000
- 折叠
摘要
目的 探讨依折麦布联合奥扎格雷钠治疗进展性缺血性脑卒中(PIS)的临床效果.方法 116 例PIS患者随机分为两组.参照组予以奥扎格雷钠治疗,联合组予以依折麦布联合奥扎格雷钠治疗.比较两组的神经功能、血管内皮功能及不良反应.结果 治疗 14d后,联合组的NIHSS评分以及血清ET-1 水平均低于参照组,血清eNOS、NO水平均高于参照组(P<0.05).结论 依折麦布联合奥扎格雷钠治疗PIS可明显减轻患者的血管内皮功能损伤,改善其神经功能,且安全性较高.
Abstract
Objective To explore the clinical effect of ezetimibe combined with ozagrel sodium in the treatment of progressive ischemic stroke(PIS).Methods 116 patients with PIS were randomly divided into two groups.The reference group was treated with ozagrel sodium,and the combined group was treated with ezetimibe combined with ozagrel sodium.The neurological function,vascular endothelial function and adverse reactions were compared between the two groups.Results After 14 days of treatment,the NIHSS score and serum ET-1 level of the combined group were lower than those of the reference group,and the serum eNOS and NO levels were higher than those of the reference group(P<0.05).Conclusions Ezetimibe combined with ozagrel sodium in the treatment of PIS can significantly reduce the damage of vascular endothelial function and improve the neurological function of patients,with high safety.
关键词
依折麦布/奥扎格雷钠/进展性缺血性脑卒中/神经功能/血管内皮功能Key words
Ezetimibe/Ozagrel sodium/Progressive ischemic stroke/Neurological function/Vascular endothelial function引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据