Analysis on the Correlations of Serum hs-CRP,IL-6 and ALT Levels with the Degree of Liver Function Damage in Patients with Hepatitis C
Objective To analyze the correlations of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and alanine aminotransferase(ALT)with the degree of liver function damage in patients with hepatitis C.Methods 124 patients with hepatitis C were selected as the observation group,124 healthy subjects were selected as the control group,and the levels of serum hs-CRP,IL-6 and ALT at admission were compared between the two groups.The levels of serum hs-CRP,IL-6 and ALT at admission in patients with different degree of liver function damage in the observation group were compared,and the correlations between the three indicators and the degree of liver function damage were analyzed.Results The levels of serum hs-CRP,IL-6 and ALT in the observation group were higher than those in the control group(P<0.05).In the observation group,the levels of serum hs-CRP,IL-6 and ALT in patients with grade A,grade B and grade C liver function damage increased in turn(P<0.05).Spearman correlation analysis showed that the levels of serum hs-CRP,IL-6 and ALT in patients with hepatitis C at admission were significantly positively correlated with their Child-Pugh classification of liver function(P<0.05).Conclusions The levels of serum hs-CRP,IL-6 and ALT are closely related to the degree of liver function damage in patients with hepatitis C.The higher the levels of serum hs-CRP,IL-6 and ALT are,the more serious the liver function damage is.
High-sensitivity C-reactive proteinInterleukin-6Alanine aminotransferaseHepatitis CLiver function damage
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