Predictive Value of Combined Detection of Serum Cys-C,UPCR and Serum Cr Levels for the Prognosis of Patients with Diabetic Nephropathy
Objective To explore the predictive value of combined detection of serum cystatin C(Cys-C),urinary protein to creatinine ratio(UPCR)and serum creatinine(Cr)for the prognosis of patients with diabetic nephropathy(DN).Methods According to mAlb/Cr ratio,100 patients with T2DM were divided into simple DM group,early DN group and clinical DN group.In addition,112 healthy subjects were selected as the control group.The serum Cys-C,UPCR and serum Cr levels of the four groups were compared.The levels of serum Cys-C,UPCR and serum Cr in DN patients with different prognosis were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of combined detection of serum Cys-C,UPCR and serum Cr levels for the prognosis of DN patients.Results The levels of serum Cys-C,UPCR and serum Cr in the control group,simple DM group,early DN group and clinical DN group increased in turn(P<0.05).The levels of serum Cys-C,UPCR and serum Cr in DN patients with good prognosis were lower than those in DN patients with poor prognosis(P<0.05).ROC curve showed that the A UC value of combined detection of serum Cys-C,UPCR and serum Cr levels in predicting the prognosis of DN patients was 0.839,higher than that of single detection of each index(P<0.05).Conclusions The levels of serum Cys-C,UPCR and serum Cr are closely related to the prognosis of DN patients.The combined detection of the above indicators can be used as an important basis for the prognosis evaluation of DN patients.
Diabetic nephropathyCystatin CUrinary protein to creatinine ratioCreatininePredictive value
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