卵巢癌组织SIRT-1、PLAGL2表达与患者临床病理参数及预后的关系分析
Analysis on the Relationships of SIRT-1 and PLAGL2 Expressions in Ovarian Cancer Tissue with the Clinical Pathological Parameters and Prognosis of Patients
宋晓娜 1卫兰 1杨文君1
作者信息
- 1. 三门峡市中心医院病理科,河南 三门峡 472000
- 折叠
摘要
目的 分析卵巢癌组织SIRT-1、PLAGL2 表达与患者临床病理参数及预后的关系.方法 选取 76 例卵巢癌患者,分析癌组织SIRT-1、PLAGL2 表达情况与临床病理参数及预后的关系.结果 Cox分析显示,FIGO分期为Ⅲ～Ⅳ期、低分化、淋巴结转移以及SIRT-1、PLAGL2 阳性表达是卵巢癌患者预后的独立影响因素(P＜0.05).结论 SIRT-1、PLAGL2在卵巢癌组织中的阳性表达率明显升高,二者的表达与临床病理参数及预后具有一定关系.
Abstract
Objective To analyze the relationships of SIRT-1 and PLAGL2 expressions in ovarian cancer tissue with the clinical pathological parameters and prognosis of patients.Methods 76 patients with ovarian cancer were selected,and the relationships of SIRT-1 and PLAGL2 expressions in cancer tissue with the clinical pathological parameters and prognosis were analyzed.Results Cox analysis showed that FIGO stageⅢ～Ⅳ,low differentiation,lymph node metastasis,and positive expressions of SIRT-1 and PLAGL2 were independent influencing factors for the prognosis of patients with ovarian cancer(P<0.05).Conclusions The positive expression rates of SIRT-1 and PLAGL2 increase significantly in ovarian cancer tissue,and their expressions are related to the clinical pathological parameters and prognosis.
关键词
卵巢癌/SIRT-1/PLAGL2/临床病理参数/预后Key words
Ovarian cancer/SIRT-1/PLAGL2/Clinical pathological parameter/Prognosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据