EDR2胶片对扫描质子碳离子束的能量响应研究
Study on the Energy Response of EDR2 Film to Scanning Proton and Carbon Ion Beams
孙威 1李永强1
作者信息
- 1. 上海市质子重离子医院 放射物理科,上海 201321;上海市放射肿瘤学重点实验室,上海 201321;上海质子重离子放射治疗工程技术研究中心,上海 201321
- 折叠
摘要
目的 研究EDR2胶片对扫描质子碳离子束的能量响应关系.方法 同一张EDR2胶片接受扫描范围为5 cm×5 cm、相同能量、9种不同剂量的均匀质子束和碳离子束照射.经冲洗扫描后,通过Image J读取2 cm×2 cm范围内像素平均值,通过计算将像素平均值转化为净光度(Optical Density,OD)值,获取该能量质子和碳离子拟合直线斜率,即剂量响应因子(Dose Response Factor,DRF).比较分析不同能量的DRF,获得EDR2胶片对不同能量质子和碳离子的响应曲线.结果 最高能(218.56 MeV)和最低能(53.04 MeV)质子的DRF值分别为0.52 OD/Gy和0.40 OD/Gy;最高能(424.89 MeV/u)和最低能(97.87 MeV/u)碳离子的DRF值分别为0.25 OD/Gy和0.11 OD/Gy.EDR2胶片对于质子和碳离子的DRF均随能量的增加而增加.结论 使用EDR2胶片测量质子碳离子束剂量,可得EDR2胶片对能量依赖性显著.使用EDR2胶片测量不同能量质子和碳离子剂量时,可使用拟合得出的能量响应曲线进行能量响应校准,提高剂量测量准确性.
Abstract
Objective To study the energy response of EDR2 film to scanning Proton and Carbon Ion Beams.Methods The same EDR2 film was irradiated by 9 kinds of uniform proton and carbon ion beams with a scanning range of 5 cm×5 cm,the same energy and different doses.After scanning,the average value of pixels within a 2 cm×2 cm area was obtained using Image J.The average value of pixels was converted to optical density(OD)value by calculation,and the slope of the fitted line representing the dose response factor(DRF)for the specific energy of protons and carbon ions was acquired.The DRFs of energies were compared and analyzed,and the response curves of EDR2 film to protons and carbon ions with different energies were obtained.Results For proton highest energy(218.56 MeV)and lowest energy(53.04 MeV),the DRF values were 0.52 OD/Gy and 0.40 OD/Gy.For carbon ion highest energy(424.89 MeV/u)and lowest energy(97.87 MeV/u),the DRF values were 0.25 OD/Gy and 0.11 OD/Gy.The DRF of EDR2 film for protons and carbon ions increased with beam energy increasing.Conclusion The EDR2 film presents significant variations of energy dependency when measuring the dose of carbon ions and protons.When using EDR2 film to measure the dose of protons and carbon ions with different energies,it is necessary to calibrate the energy response to improve the accuracy.
关键词
EDR2胶片/剂量响应因子/能量响应/净光度Key words
EDR2 film/dose response factor/energy response/optical density引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据