Study of Left Atrial Function in Hyperuricemia Patients Based on Four-Dimensional Left Atrial Automatic Quantification
Objective To study the mechanical changes of the left atrial myocardium in hyperuricemia patients using four-dimensional left atrial automatic quantification(4D LAQ)and to quantitatively evaluate the early remodeling characteristics of the left atrium.Methods A total of 86 hyperuricemia patients and 35 healthy controls were randomly selected in our hospital from June to December 2022.The 4D LAQ was used to study the deformation characteristics of the left atrial myocardium on the basis of conventional two-dimensional echocardiography(2DE).Global longitudinal strain(LASr、LAScd、LASct)and circumferential strain(LASr_c、LAScd_c、LASct_c)values of the left atrium myocardium during ventricular systolic,early diastolic and late diastolic phase were obtained by 4D LAQ,and the left atrial maximum volume(LAVmax)and LAVmax index(LAVmaxI)were acquired at the same time.The left atrial anteroposterior diameter(LAD),left ventricular end-diastolic diameter(LVEDD),left ventricular fractional shortening(FS),left ventricular ejection fraction(LVEF),stroke volume(SV),and the ratio of peak flow velocity during early and late diastolic of mitral valve(E/A)were measured by 2DE.According to the LAVmaxI value,50 hyperuricemia patients with LAVmaxI<34 mL/m2 were selected as the experimental group(hyperuricemia group),and 35 healthy individuals were selected as the control group.Results Compared with the control group,LASr_c,LAScd_c and E/A were significantly decreased in the hyperuricemia group(P<0.001).There was no significant difference in LASr,LAScd,LASct,LASct_c,LAVmax,LAVmaxI,and conventional two-dimensional parameters including LAD,LVEDD,FS,LVEF,and SV(P>0.05).Patient blood uric acid level were associated with LASr_c(r=-0.68,P<0.001),LAScd_c(r=0.72,P<0.001)and E/A(r=-0.74,P<0.001),but was no significant association with LASr,LAScd,LASct,LASct_c,LAVmax,LAVmaxI,LAD,LVEDD,FS,LVEF,SV,age,blood glucose,blood lipid,and blood cholesterol(P>0.05).Conclusion The 4D LAQ technology can effectively evaluate the early left atrial myocardial mechanical changes in patients with hyperuricemia,especially the left atrial circumferential strain,provides a new method for clinical comprehensive evaluation of the condition of hyperuricemia patients.
four-dimensional left atrial automatic quantificationhyperuricemialeft atrial functionleft atrial myocardial mechanical
万方数据
维普
