首页|18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布

18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-18F-2-脱氧-β-D葡萄糖,简称18F-FDG-(OAc)4]的稳定性和实用性.方法 基于合成器及其合成工艺流程,进行18F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析.结果 连续3批合成18F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8～0.9),放射性核纯度为100%.18F-FDG-(OAc)4与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05).结论 正电子药物合成器合成18F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性.
Synthesis of 18F-FDG-(OAc)4 and Its Bio-Distribution in Mice
Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of 18F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of 18F-FDG-(OAc)4 were carried out,and the similarities and differences in biological distribution in mice between 18F-FDG-(OAc)4 and 18F-FDG were analyzed.Results The success rate of 18F-FDG-(OAc)4 in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting 18F-FDG-(OAc)4 and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of 18F-FDG-(OAc)4 with high synthesis success rate and yield,showing strong stability and practicality.

18F-FDG-(OAc)418F-FDGsynthesis of imaging agentsbio-distribution

何正中、庞丁华、李宁、张实来、杨洪、蒙小飞、杨志、肖国有

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广西医科大学附属肿瘤医院 核医学科(广西临床重点建设专科),广西 南宁 530021

18F-FDG-(OAc)4 18F-FDG 显像剂制备 生物分布

广西科技计划项目重点研发计划广西生物靶向诊治研究重点实验室开放基金课题广西生物靶向诊治研究重点实验室开放基金课题广西生物靶向诊治研究重点实验室开放基金课题广西壮族自治区卫生健康委员会自筹经费科研课题广西壮族自治区卫生健康委员会自筹经费科研课题广西壮族自治区卫生健康委员会自筹经费科研课题广西高校中青年教师科研基础能力提升项目广西医科大学青年科学基金项目广西医科大学青年科学基金项目

桂科AB19110015GXSWBX202203GXSWBX202204GXSWBX202205Z20190559Z-A20220680Z-A202206782023KY0084GXMUYSF202226GXMUYSF202356

2024

10.3969/j.issn.1674-1633.2024.05.005

中国医疗设备
中国整形美容协会

中国医疗设备

CSTPCD
影响因子：0.825
ISSN：1674-1633
年,卷(期)：2024.39(5)
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