18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布
Synthesis of 18F-FDG-(OAc)4 and Its Bio-Distribution in Mice
何正中 1庞丁华 1李宁 1张实来 1杨洪 1蒙小飞 1杨志 1肖国有1
作者信息
- 1. 广西医科大学附属肿瘤医院 核医学科(广西临床重点建设专科),广西 南宁 530021
- 折叠
摘要
目的 分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-18F-2-脱氧-β-D葡萄糖,简称18F-FDG-(OAc)4]的稳定性和实用性.方法 基于合成器及其合成工艺流程,进行18F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析.结果 连续3批合成18F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8～0.9),放射性核纯度为100%.18F-FDG-(OAc)4与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05).结论 正电子药物合成器合成18F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性.
Abstract
Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of 18F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of 18F-FDG-(OAc)4 were carried out,and the similarities and differences in biological distribution in mice between 18F-FDG-(OAc)4 and 18F-FDG were analyzed.Results The success rate of 18F-FDG-(OAc)4 in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting 18F-FDG-(OAc)4 and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of 18F-FDG-(OAc)4 with high synthesis success rate and yield,showing strong stability and practicality.
关键词
18F-FDG-(OAc)4/18F-FDG/显像剂制备/生物分布Key words
18F-FDG-(OAc)4/18F-FDG/synthesis of imaging agents/bio-distribution引用本文复制引用
基金项目
广西科技计划项目重点研发计划(桂科AB19110015)
广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202203)
广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202204)
广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202205)
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559)
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220680)
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220678)
广西高校中青年教师科研基础能力提升项目(2023KY0084)
广西医科大学青年科学基金项目(GXMUYSF202226)
广西医科大学青年科学基金项目(GXMUYSF202356)
出版年
2024
国家科技期刊平台
NSTL
万方数据