摘要
目的 探讨半衰期测定法在医用正电子(18F、11C、13N)核素纯度测定和分析中的方法.方法 通过回旋加速器加速质子分别轰击重氧水、氮氧混合气及乙醇(20 mmol/L)靶水,分别产生18F、11C、13N正电子核素样品水溶液.18F、11C、13N核素分别每间隔10、2、2 min测量样品水溶液放射性活度,放射性活度测定次数为5次.根据放射性核素衰变的线性拟合公式,计算核素半衰期T1/2.通过γ能谱仪测定对应样品水溶液,鉴定样品放射性核素纯度.结果 由半衰期测定法计算可得3种正电子核素的半衰期与γ能谱仪法测定得半衰期结果相近,18F、11C、13N样品的放射性核素半衰期分别为(110.07±0.53)、(19.62±0.77)、(10.02±0.94)min.通过γ能谱仪测定对应样品的18F、11C、13N核素纯度均为100%,其物理半衰期分别为109.77、20.39、9.97 min.结论 半衰期测定法具有测定医用放射性核素纯度的可行性,值得推广应用.
Abstract
Objective To explore the application of half-life assay in the purity determination and analysis of medical positron nuclides(18F,11C,13N).Methods A cyclotron was used to accelerate proton bombardment of heavy oxygen water,nitrogen oxygen mixture,and ethanol(20 mmol/L)target water,respectively,to produce aqueous solutions of 18F,11C,and 13N positron nuclide samples.The radioactivity of the sample aqueous solution was measured every 10,2,and 2 min for 18F,11C,and 13N nuclides,and the number of radioactivity measurements was 5.According to the linear fitting formula of radioactive nuclide decay,the half-life T1/2 of the nuclide was calculated.The radionuclide purity of the sample was determined by γ-energy spectrometer.Results The results showed that the half-lives of three positron nuclides calculated by the half life measurement method was similar to that of the γ-spectrometer method,and the half-lives of radioactive nuclides in 18F,11C,and 13N samples were(110.07±0.53),(19.62±0.77),and(10.02±0.94)min,respectively,calculated using the half-life measurement method.The purity of 18F,11C,and 13N nuclides in the corresponding samples determined by the energy spectrometer was 100%,and their physical half-lives were 109.77,20.39,and 9.97 min.Conclusion The half-life determination method has the feasibility of determining the purity of medical radioactive nuclides,which is worth promoting and applying.
基金项目
广西壮族自治区重点研发计划(桂科AB19110015)
广西医科大学青年科学基金(2023)(GXMUYSF202356)
广西生物靶向诊治研究重点实验室开放基金(GXSWBX202203)
广西生物靶向诊治研究重点实验室开放基金(GXSWBX202204)
广西生物靶向诊治研究重点实验室开放基金(GXSWBX202205)
广西卫生健康委自筹经费科研课题(Z20190559)
广西卫生健康委自筹经费科研课题(Z-A20220680)
广西卫生健康委自筹经费科研课题(Z-A20220678)
广西卫生健康委自筹经费科研课题(Z-A20220711)
国家科技期刊平台
NSTL
万方数据