Study on NIC Based on DECT in Evaluating Liver Function Grading in Patients with Cirrhosis
Objective To explore the value of noninvasive evaluation of liver function grading in patients with cirrhosis based on normalized iodine concentration(NIC)obtained by dual-energy CT(DECT),and determine the optimal extraction phase of NIC.Methods A prospective collection of patients who underwent abdominal DECT scan in our hospital from May 2022 to October 2023 was conducted.A total of 68 patients with cirrhosis diagnosed clinically/pathologically were screened,and 25 healthy control patients were selected.The portal venous NIC and the extended NIC were calculated by obtaining iodine values during the portal venous phase and 3 min extended phase of DECT scanning,and the albumin-Bilirubin(ALBI)score was used for liver function grading(ALBI grade 1=25 cases;ALBI grade 2=23 cases;ALBI grade 3=20 cases).Spearman correlation was used to analyze the correlation between NIC and ALBI grade;Kruskal-Wallis H test was used to compare the differences of NIC among groups;the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of NIC in differentiating different ALBI grades,and the area under curve(AUC)of ROC was calculated.Results The NIC in portal venous phase was negatively correlated with ALBI grade(r=-0.83,P<0.01);NIC in extended phase was positively correlated with ALBI grade(r=0.68,P<0.01).The AUC of NIC in portal venous phase in differentiating different ALBI grades was 0.84,0.83,0.82 respectively;the AUC of NIC in differentiating different ALBI grades in the extended phase were 0.79,0.72,0.65,respectively.The evaluation efficiency of NIC in the two phases was further improved after the combination.Conclusion The NIC obtained based on DECT can be used as a reliable index to evaluate liver function in patients with cirrhosis,and the efficacy of portal venous phase NIC in evaluating liver function is better than that of extended phase NIC.In addition,the joint evaluation of liver function by two phases NIC is better.
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