Application of Hybrid Radiotherapy Technology in Whole Brain Radiotherapy
Objective To compare the dosimetric differences among hybrid radiotherapy technology,intensity modulated radiotherapy(IMRT),volumetric modulate arc therapy(VMAT),and three-dimensional conformal radiotherapy(3DCRT)in whole brain radiotherapy,and to investigate the feasibility of hybrid radiotherapy technology in whole brain radiotherapy.Methods A total of 25 patients who required whole brain radiotherapy were selected and designed with 3DCRT plan,hybrid plan based on IMRT technology(Hybrid-IMRT),hybrid plan based on VMAT technology(Hybrid-VMAT),IMRT plan,and VMAT plan.The same optimization parameters were all used by the Hybrid-IMRT plan and IMRT plan,as well as the Hybrid-VMAT plan and VMAT plan.60%of the prescription dose(2400 cGy/20 F)was provided by 3DCRT portion of the two mixed plans,while the remaining 40%of the prescription dose(1600 cGy/20 F)was provided by the IMRT or VMAT portion.The target homogeneity index,conformity index,maximum dose to the target area,monitor unit,and the maximum dose to organs at risk(lenses,eyeballs,optic nerves,optic chiasm,and brainstem)of the five plans were compared.Results All indicators of the five plans met the clinical requirements.The homogeneity of target area,maximum dose point of target area,dose of crystal,optic chiasma and brainstem of Hybrid-IMRT and Hybrid-VMAT plans were better than those of IMRT and VMAT plans,and the differences were statistically significant(P<0.05).Compared with IMRT and VMAT plans,there were significant differences in target conformity and eyeball receptivity(P<0.05).The monitor units of Hybrid IMRT and Hybrid VMAT plans decreased by 60%and 10%respectively compared to IMRT and VMAT plans(P<0.05).Conclusion The parameters of Hybrid-IMRT and Hybrid-VMAT plans can meet the requirements of clinical treatment,with better homogeneity of target area,shorter treatment time,and better protection of endangered organs far away from and within the target area.Therefore,hybrid irradiation technology can be applied to whole brain radiotherapy.
万方数据
维普
