The chemical constituents from Pittosporum kerrii Craib (Ⅰ)
The chemical constituents of Pittosporum kerrii Craib were studied. Six compounds were isolated from this plant by column chromatogramphies of silica gel. Their structures were identified by spectral data analy-sis. All these compounds were isolated for the first time from this plant. These are;a-spinasterol(1) ;β- stig-masterol (2) ; uvaol (3) ; α-spinasterol -3 -O -β -D-glucopyranoside (4) ;β-stigmasterol -3-O-β-D-glucopyranoside (5) ; luteolin (6). Cytotoxicity screening of extracts and the six compounds from Pittosporum kerrii Craib was carried out by HL60 cell. Two extracting fractions of chloroform and ethyl acetate, and three compounds (1,3 ,6) possess cytotoxic activities and the IC50 are 6.5, 5.0, 10. 0,9.5 μg/mL and 6. 0 μg/mL for HL60,re-spectively.
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万方数据
维普
