云南大学学报(自然科学版)2024,Vol.46Issue(1) :151-157.DOI:10.7540/j.ynu.20230017

锯叶棕果实化学成分分离鉴定及抗前列腺炎活性研究

Isolated and identified of chemical constituents from serenoa serrulata fruit and their anti-prostatitis activity

郝丽亚 李冰洁 王中林 郑新华
云南大学学报(自然科学版)2024,Vol.46Issue(1) :151-157.DOI:10.7540/j.ynu.20230017

锯叶棕果实化学成分分离鉴定及抗前列腺炎活性研究

Isolated and identified of chemical constituents from serenoa serrulata fruit and their anti-prostatitis activity

郝丽亚 1李冰洁 1王中林 1郑新华1
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作者信息

  • 1. 平顶山学院医学院,河南平顶山 467000
  • 折叠

摘要

研究了锯叶棕果实化学成分及其抗前列腺炎活性.采用硅胶、Sephadex LH-20 对锯叶棕果实提取物进行分离纯化,得到 26 个化合物,根据理化性质和波谱数据鉴定了化合物结构.测试所得化合物的抗前列腺炎活性,结果显示,化合物 triterpenoster、scopoletin、cannabispiran、1,3,7-trihydroxy-6-methyl-anthraquinone、podophyllotoxin、vanillil、isopropylidenkirenol具有一定的抗前列腺炎活性.所有化合物均为首次从锯叶棕果实中分离得到.

Abstract

The chemical constituents from serenoa serrulata fruit and their anti-prostatitis activity were studied.The extracts from serenoa serrulata fruit were isolated and purified by silica gel and Sephadex LH-20.Twenty-six compounds were isolated and identified from serenoa serrulata fruit.And their structures were identified according to physicochemical properties and spectral data.The antiprostatitis activity of the compound was tested.The results showed that compounds triterpenoster,scopoletin,cannabispiran,1,3,7-trihydroxy-6-methyl-anthraquinone,podophyllotoxin,vanillil and isopropylidenkirenol showed certain anti-prostatitis activity.All compounds were isolated from serenoa serrulata fruit for the first time.

关键词

锯叶棕果实/化学成分/分离鉴定/抗前列腺炎活性

Key words

serenoa serrulata fruit/chemical constituents/isolated and identified/anti-prostatitis activity

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基金项目

河南省高等学校重点科研项目(21B310005)

出版年

2024
云南大学学报(自然科学版)
云南大学

云南大学学报(自然科学版)

CSTPCDCSCD北大核心
影响因子:0.663
ISSN:0258-7971
参考文献量24
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