In this paper,four thiourea catalysts containing chiral carbon and C2 chiral axis were designed and synthesized successfully,and they were used for the asymmetric synthesis of spiral[cyclopropane-indole oxide]compounds.The experimental results showed that the synthesis of spiro[cyclopropane-oxyindole]obtained better yield(89%)and higher enantioselectivity(87%)at room temperature 25℃with 10 mol%3a as catalyst and CHCl3 as solvent.The reaction has the advantages of friendly environment,mild reaction condition and cheap catalyst.This method provides an important way for the synthesis of snail[cyclopropane-oxyindole]skeleton with biological pharmacological activity.
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