Sephadex LH-20,silica gel column chromatography,macroporous resin column chromatography and other separation methods were comprehensively used to separate and purify the ethyl acetate phase of Morus macroura Miq.,and 1D and 2D NMR were used to identify the structure.Nine lignan compounds were isolated and purified,namely moricin O(1),moricin P(2),moricin M(3),moricin R(4),(-)-(7R,8S)-dihydroniconiferol alcohol(5),(+)-laricilinol(6),balanophonin(7),(7S,8R)-5-methoxyl balanophonin(8)and hedyotisol A(9),among which compounds 1,4-9 were firstly isolated from this plant.In addition,some compounds(1-5,7,9)were tested for anti-inflammatory activity,and compound 9 showed weak anti-inflammatory activity.
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