The chemical constituents and antitumor activity of Rhododendron decorum were studied.Twenty compounds were isolated from the EtOAc extract of this plant by silica gel,sephadex LH-20 and RP-18 column chromatography,and CCK-8 method were used to test the antitumor activity in vitro.They were identified as decorumtone(1),confluentin(2),o-methy-llasiodiplodin(3),daurichromenes A(4),arthproliferin B(5),grayanotoxin-Ⅰ(6),grayanotoxinⅣ(7),(Z)-9,10-dihydroxy-6,10-dimethyl-5-undecen-2-one(8),8-hydroxy-6,7-dihydrolinalool(9),(E)-2,6-dimethyl-2,7-octadiene-1,6-diol(10),9-hydroxy-4,7-megastigmadien-3-one(11),vomifoliol(12),dehydrovomifoliol(13),euscaphic acid(14),kaempferol(15),afzelin(16),avicularin(17),aromadedrin-3-O-α-L-arabinopyranoside(18),noreugenin(19),scopoletin(20)on the basis of physicochemical properties and spectral data.Those compounds have no significant activity against to the cell lines A-549,HepG2,Hela-60,MDA-MB-68.Compound 1 was a new natural product,Compounds 1-5,7-20 were isolated from Rhododendron decorum.for the first time.
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