In this paper,polysubstituted indolizine derivative 3 was synthesized with ethyl pyridine acetate 1 and benzyl bromide 2 as raw materials,triethyl orthoformate as additive and Cs2CO3 as base in acetonitrile solution by reflux reaction for 7 h.The yield was medium to excellent.It was also found that triethyl orthoformate had water absorption in the reaction system.The synthesized products were characterized by 1H NMR,13C NMR and HRMS.The method described in the paper highlights the advantages of easily accessible raw materials,simple reaction procedure,and a straightforward synthesis route.This method offers a new approach for the synthesis of potential bioactive indolizine derivatives,which could be useful in the discovery of new drug candidates or bioactive compounds.
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