An Analytical Method for Related Substances in Dihydroergotine Methanesulfonate Sustained Release Tablets by HPLC
Objective:To established and optimized a HPLC method for the determination of related substances in dihydroergot methanesulfonate sustained-release tablets.Methods:A single factor method was used to screen and develop sample processing methods.The chromatographic conditions for HPLC detection were optimized,with a focus on optimizing the mobile phase pH value,buffer salt concentration,and elution gra-dient.Results:The developed method was highly specific and could effectively separate samples and degradation products,and the peak purity and mass balance were satisfactory.Conclusion:This method was simple and accurate,and could be used for the determination of related sub-stances in dihydroergot methanesulfonate sustained-release tablets.
dihydroergotoxine methanesulfonatesustained release tabletsrelated substancesmethod development
万方数据
维普
