克唑替尼的合成工艺研究进展
Research progress on the synthetic technology of Crizotinib
杨贵严 1沈原源 1张莹 1施怡 1何泉莹 1林睿 2王连霞 3滕明瑜1
作者信息
- 1. 云南师范大学 化学化工学院,云南 昆明 650500
- 2. 云南师范大学 图文信息中心,云南 昆明 650500
- 3. 重庆西南铝医院,重庆 401326
- 折叠
摘要
主要介绍了国内外克唑替尼(Crizotinib)及其关键手性中间体(S)-1-(2,6-二氯-3-氟苯基)乙醇的相关合成工艺路线,对其进行分析后指出了存在的问题及优点,最终总结出了较好的合成工艺路线,为相关研究人员快速了解克唑替尼其关键手性中间体的合成工艺提供参考.
Abstract
In this paper,the synthetic processes of Crizotinib and its key chiral intermediate(S)-1-(2,6-dichloro-3-fluorophenyl)eth-anol were introduced,and the problems and advantages of each process were pointed out.Finally,the synthetic process was summarized.It pro-vides references for relevant readers to quickly understand the synthesis process of crizotinib and its key chiral intermediates.
关键词
克唑替尼/关键手性中间体/非小细胞肺癌/化学合成Key words
Crizotinib/Key Chiral Intermediates/Non-small Cell Lung Cancer/Chemical Synthesis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据