CO-CO2体系合成氘代甲醇热力学分析及正交优化
Thermodynamic Analysis and Orthogonal Optimization of Synthesis of Deuterated Methanol Catalyst in CO-CO2 System
龙涛 1周锋 1张伟 1吴泓 2王建 2陈霖2
作者信息
- 1. 湖南凯美特气体股份有限公司,湖南 岳阳 414020
- 2. 中南大学 冶金与环境学院,湖南 长沙 410083
- 折叠
摘要
作为一种重要的化工原料和氘代中间体,氘代甲醇(CD3OD)被广泛应用于核磁共振试剂、氘代药物中间体、光电材料改性,但其在CO-CO2体系中的催化合成效率仍有待提高.文章通过热力学计算CO-CO2加D2制备氘代甲醇反应条件对反应物平衡转化率的影响,并采用CuO/ZnO/Al2O3催化剂,设计正交实验探索合成氘代甲醇的最佳反应条件.以氘代甲醇时空产率为指标,实验获得的最优反应条件为:反应温度240 T,反应压强 5 MPa;n(D2)/n(CO+CO2)为 3,n(CO)/n(CO2)为 1.
Abstract
As an important chemical raw material and deuterated intermediate,deuterated methanol(CD3OD)has been widely used in nuclear magnetic resonance reagents,deuterated drug intermediates and photoelectric materials modification,but its catalytic synthesis efficiency in CO-CO2 system still needs to be improved.Herein,the effect of reaction conditions on the equilibrium conversion rate during the process of prepara-tion of deuterated methanol from CO-CO2 and D2 is calculatedally.In the case of CuO/ZnO/Al2O3 catalyst,the optimal reaction conditions for the synthesis of deuterated methanol is investigated by orthogonal experiment.Taking the space-time yield of deuterated methanol as the index,the optimal reaction conditions obtained in the experiment are as follows:the reaction temperature is 240 ℃,the reaction pressure is 5 MPa;the molar ratio of D2/(CO+CO2)is 3,and the molar ratio of CO/CO2 is 1.
关键词
氘代甲醇/热力学/合成条件优化Key words
Deuterated Methanol/Thermodynamic/Optimization of Synthetic Conditions引用本文复制引用
基金项目
国家重点基础研究发展计划(2018YFC1901604)
湖南省自然科学基金(2023JJ30667)
中南大学研究生教育教学改革项目(2021JGB117)
出版年
2024
国家科技期刊平台
NSTL
万方数据