In recent years,drug-loaded microsphere preparation prepared by biodegradable polymer materials can be slowly controlled release,which is a research hotspot of high-end new pharmaceutical preparations.The key factor in the preparation of microsphere preparations lies in the selection of suitable polymer materials and production technology.However,the preparation process of microspheres is complicated and the quality control is difficult,which is only applied in a few products.Now more and more oral biological drugs are difficult to absorb,and slow-release microspheres are much attention in improving patient compliance.This review analyzes the classic microsphere preparation technology and some new techniques of microsphere preparation,and summarizes the morphology,size,particle distribution,drug loading,sealing rate and release degree of microsphere preparations,in order to provide some reference value for the research of microsphere preparations.
国家科技期刊平台
NSTL
万方数据
