Study on Preparation of Mask Mate Cool Refreshing Hydrogel Patch
(Objective)To prepare an oil of peppermint gel patch,which is attached to the inner wall of a mask,to optimize the mask wearing for prolonged wear,such as boredom,mental fatigue,stench.(Methods)The raw materials are polyvinyl alcohol(PVA)and chitosan(CS).The oil of peppermint/PVA/CS composite hydrogel patch is prepared by cyclic freezing/thawing method.The optimum preparation process is optimized by RSM,and the optimum drug loading of the oil of peppermint is determined by single blind method.(Results)The optimal preparation conditions are as follows:PVA/CS ratio 5.3:1,freezing time 12.5 h,freezing times 4 times,oil of peppermint 0.5％～0.6％.(Conclusion)The hydrogel patch prepared by RSM has the advantages of good viscosity,easy to use,small size,long lasting fragrance,safe,non-toxic,non-irritant and so on.It is reasonable and feasible to optimize the preparation process of oil of peppermint.
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