This article investigates the irritation of second-generation acrylic adhesive(SGA)to the skin,with particular attention to its rela-tionship with allergic skin diseases.The experiment explored the barrier effect of gloves made of different materials on SGA,and found that dis-posable natural rubber gloves are prone to swelling after contact with adhesive,while adding a layer of disposable PE gloves can effectively pre-vent the penetration of adhesive and the penetration of allergenic components.