Exploration of Experimental Teaching in Pharmaceutical Engineering Under the Background of New Engineering——A Comprehensive Experiment Based on Mitoxantrone Prodrug is Recommended
Under the background of new engineering,the manufacturing industry puts forward higher requirements for the innovation ability of pharmaceutical professionals.In this paper,we took the synthesis and properties of mitoxantrone prodrug as the experimental content,and rec-ommended a comprehensive experiment for pharmaceutical engineering undergraduate majors.In this comprehensive experiment,mitoxantrone was structurally modified by organic synthesis to obtain the target prodrug.The structure of the prodrug was characterized by nuclear magnetic resonance and mass spectrometry.The release response of prodrug was performed on mass spectrometry and highperformance liquid chromatogra-phy.The selectivity of prodrug to cancer cells was investigated with cytotoxicity test.The comprehensive experiment covers drug synthesis,struc-tural characterization,drug release toxicity analysis,etc.,which is helpful to the cultivation of innovative talents in pharmaceutical engineer-ing.
New EngineeringComprehensive ExperimentExperiment TeachingProdrug
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