Study on the analgesic and anti-inflammatory activity of the leaves of Aquilaria sinensis
The pharmacological effects of agarwood leaf alcohol extract on anti-inflammatory and analgesic effects were studied,and the mechanism of action was preliminarily studied.Study and mechanism anti-inflammatory and analgesic activity and mechanism of the leaves of Aquilaria sinensis.Using the classical pain stimulation(hot plate method,acetic acid twist)model and the mouse auricular swelling anti-inflammatory model,the alcoholic extract of the leaves of A.sinensis was evaluated in terms of their anti-inflammatory and analgesic effects.The ethanol ex-tract of leaves of A.sinensis can significantly reduce the number of writhing in mice,increase the pain threshold of mice,and has a significant inhibitory effect on xylene induced auricle swelling in mice.The leaves of A.sinensis has anti-inflammatory effect and analgesic effect on mice,which may be related to the reduction of inflammatory factors TNF-α and IL-β and the increase of anti-inflammatory factors IL-4 and IL-10 in mouse ear tissue and may be related to the reduction of PGE2 and BK in mice serum and the increase of β-EP content,respectively.
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