Repeated administration toxicity study of freeze-dried powder of Poecilobdellamanillensis
In order to provide scientific evidences for the medicinal safety of freeze-dried powder of Poecilobdella-manillensis,repeated administration toxicity tests were taken and the toxic reaction and the severity of toxicity reac-tion produced in SD rats were observed.The SD rats were randomly assigned to solvent control group(sterile water for injection),high,medium and low doses groups(3.24,1.08 and 0.54 g·kg-1).The dose concentration was 205.5,67.5 and 33.75 mg·mL-1 and the administered volume was calculated as weekly body weight.All SD rats were administered 6 days weekly for six months,and recovered for 8 weeks after the last administration.Then we de-tected SD rats'clinical index,organ weighing,hematological examination,serum biochemical examination and his-topathological examination to evaluate toxicological safety.The results showed that no toxicity changes related to the testing were found for each index after 6 months of continuous administration in SD rats.In the conditions of this ex-periment,SD rats were treated with high,medium,and low doses of freeze-dried powder of Poecilobdellamanillen-sis,no significant toxic effects were observed.
freeze-dried powder of PoecilobdellamanillensisSD ratsrepeated administration toxicity
万方数据
维普
