Study on preparation method of Cinnamon formula granules based on standard soup
This study is to establish a preparation method of Cinnamomum cassia formula granules which meets the requirements of accompanying standard decoction.The characteristic map of Cinnamon standard decotion and formu-la particles was established.The volatile components and water-soluble components were identified by volatile oil and water extract.The ratio of volatile components to water-soluble components in the characteristic atlas of Cinna-momum cassia standard decoction and Cinnamomum cassia formula granules was collected.Taking the ratio H in Cinnamomum cassia Standard decoction as reference and using the ratio,the volatile oil inclusion compound and concentrated solution in the preparation process of Cinnamomum cassia formula particles were mixed.Five charac-teristic peaks were determined by UPLC characteristic map,among which the peaks 1～4 were protocatechuic acid,coumarin,cinnamic acid and cinnamaldehyde,respectively.Cinnamaldehyde was confirmed as volatile component,and the other components were divided into water-soluble components.According to the ratio relationship between volatile components and water-soluble components,the blending formula of volatile oil inclusion complex and con-centrated solution was established on the basis of defining the inclusion rate and the yield rate of the inclusion com-plex.The H ratio of Cinnamon formula particles prepared by this formula is consistent with that of Cinnamomum cas-sia standard decoction.For the first time,the blending method of volatile oil inclusion compound and concentrated solution in the preparation of Cinnamon formula particles was established by using characteristic atlas for the first time.The method is simple to operate,can ensure the consistency of volatile components and water-soluble compo-nents,and has guiding significance and reference value for the production of Cinnamomum cassia formula particles.
万方数据
维普
