Investigating the mechanism of Erzhi pill for the treatment of seborrheic alopecia based on network pharmacology and molecular docking
This study aims to explore the mechanism of action of Erzhi pill in the treatment of seborrheic alopecia based on network pharmacology and molecular docking.The drug composition information of Erzhi pill was searched and collect-ed through TCMSP database,the disease targets related to seborrheic alopecia were collected through Disgenet,TTD,OMIM,Genecards,Drugbank and other databases,the active drug composition targets were predicted using Swiss Target Prediction,and the active drug composition and The PPI network map was constructed using String database and Cyto-scape 3.7.2 software,GO bioannotation and KEGG pathway enrichment analysis were performed by Metascape database and visualized by Cytoscape 3.7.2 to construct the target and pathway network map.Ths results are as follows:fifteen ac-tive ingredients and 170 targets were collected and screened for Erzhi pill,533 targets related to seborrheic alopecia and 44 common targets,among which AKT1,VEGFA,IL6,TNF,PPARG,ERBB2,ESR1 had the most significant interactions,which were involved in,cancer pathway,lipid and atherosclerosis,AGE-RAGE signalling pathway in diabetic complica-tions,PI3K-Akt signalling pathway,IL-17 signalling pathway,prostate cancer,bladder cancer,tumour necrosis factor sig-nalling pathway,proteoglycan in cancer and 147 other signalling pathways.Er Zhi Wan can treat seborrheic alopecia by inhibiting inflammation in vivo,improving the oxidative stress response of hair follicle cells,regulating lipids and nouris-hing the liver and kidney,and promoting local vascularization of the scalp,reflecting the multi-component,multi-target and multi-pathway pharmacological characteristics of Er Zhi Wan in the treatment of seborrheic alopecia.
万方数据
维普
