Secondary metabolites of endophytic fungus Penicillium chrysogenum derived from Paris polyohylavar.Yunnanensis
Nine compounds were isolated from endophytic fungus Penicillium chrysogenum YNCA1212 derived from Paris polyohylavar.Yunnanensis by chromatographic methods.Their structures were elucidated as macrophorin A(1),macrophorin D(2),peniginsengin A(3),dihydrodemethylsorbicillin(4),2',3'-dihydrosorbicillin(5),(2E,4E)-1-(2,6-dihydroxy-3,5-dimethyl-phenyl)hexa-2,4-dien-1-one(6),(S)-penipra-tynolene(7),3,5-dihydroxytoluene(8),N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide(9).Compound 6 showed weak antimicrobial activity against Staphylococcus aureus(IC50=136.7 μg/mL).