首页|苦瓜多糖联合有氧运动对2型糖尿病大鼠糖脂代谢紊乱的改善作用及其机制

苦瓜多糖联合有氧运动对2型糖尿病大鼠糖脂代谢紊乱的改善作用及其机制

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[目的]研究苦瓜多糖联合有氧运动对 2型糖尿病(type 2 diabetes mellitus，T2DM)大鼠糖脂代谢紊乱的作用及其机制。[方法]将T2DM大鼠随机分为模型组、有氧运动组、苦瓜多糖组及苦瓜多糖联合有氧运动组(联合组)，另设正常组;苦瓜多糖组及联合组大鼠灌胃 200 mg/kg苦瓜多糖，有氧运动组及联合组大鼠进行有氧运动，连续干预 8周。[结果]与模型组相比，有氧运动组、苦瓜多糖组及联合组大鼠空腹血糖(fast-ing blood glucose，FBG)、空腹胰岛素(fasting insulin，FINS)、胰岛素抵抗指数(insulin resistance，HOMA-IR)及血清低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL-C)、总胆固醇(total cholesterol，TC)、甘油三酯(triglyceride，TG)、丙二醛(malondialdehyde，MDA)、C反应蛋白(C-reactive protein，CRP)、肿瘤坏死因子α(tumor necrosis factor-α，TNF-α)和白细胞介素 6(interleukin-6，IL-6)的水平显著降低(P＜0。05)，而血清高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL-C)、谷胱甘肽过氧化物酶(glutathione peroxi-dase，GSH-Px)、超氧化物歧化酶(superoxide dismutase，SOD)及骨骼肌组织磷脂酰肌醇 3-激酶p85(phos-phatidylinositol 3-kinase p85，PI3Kp85)、磷酸化蛋白激酶B(phosphorylated protein kinase B，p-Akt)的水平显著增加(P＜0。05);与有氧运动组和苦瓜多糖组相比，联合组大鼠FBG、FINS、HOMA-IR及血清LDL-C、TC、TG、MDA、CRP、TNF-α、IL-6的水平进一步显著降低(P＜0。05)，而血清HDL-C、GSH-Px、SOD及骨骼肌组织 PI3Kp85、p-Akt的水平进一步显著增加(P＜0。05)。[结论]苦瓜多糖联合有氧运动可以改善T2DM大鼠的糖脂代谢紊乱，其机制涉及抗氧化、抑制炎症反应及调节PI3K/Akt信号通路。
Effects and Mechanisms of Bitter Gourd Polysaccharide Com-bined with Aerobic Exercise on Glucose and Lipid Metabolism Disorders in Rats with Type 2 Diabetes Mellitus
[Purpose]To investigate the effects and mechanisms of bitter gourd polysaccharide(BGP)combined with aerobic exercise(AE)on glucose and lipid metabolism disorders in rats with type 2 diabetes mellitus(T2DM).[Methods]T2DM rats were randomly divided into a model group,AE group,BGP group,BGP combined with AE group(combined group),and a normal group.Rats in BGP group and combined group received oral administration of 200 mg/kg BGP,while rats in AE group and combined group underwent aerobic exercise training.The intervention period lasted for eight weeks.[Results]Compared to the model group,the AE group,BGP group and combined group of rats showed a significant decrease in fasting blood glucose(FBG),fasting insulin(FINS),in-sulin resistance index(HOMA-IR),serum low density lipoprotein cholesterol(LDL-C),total choles-terol(TC),triglyceride(TG),malondialdehyde(MDA),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels(P＜0.05);however,high density lipoprotein choles-terol(HDL-C),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),phosphatidylinositol 3-kinase p85(PI3Kp85)in skeletal muscle tissue and phosphorylated protein kinase B(p-Akt)levels showed a significant increase(P＜0.05).Compared to the AE group and BGP group,the combined group showed a further significant decrease in FBG,FINS,HOMA-IR,serum LDL-C,TC,TG,MDA,CRP,TNF-α,and IL-6(P＜0.05);additionally,the levels of serum HDL-C,GSH-Px,SOD,and PI3Kp85 and p-Akt in skeletal muscle tissue were further significantly increased(P＜0.05).[Conclusion]The combination of BGP and AE is found to improve glucose and lipid metabolism disorders in rats with T2DM.The underlying mechanisms involve antioxidant effects,inhibition of in-flammatory response and regulation of the PI3K/Akt signaling pathway.

bitter gourd polysaccharideaerobic exerciseglucose and lipid metabolismoxidative stressinflammatory response

祁文文、梁益军

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郑州航空工业管理学院体育与公共艺术部,河南郑州 450046

桂林电子科技大学体育部,广西桂林 541004

苦瓜多糖 有氧运动 糖脂代谢 氧化应激 炎症反应

新世纪广西高等教育教学改革工程项目

2014JGB140

2024

10.12101/j.issn.1004-390X(n).202306028

云南农业大学学报
云南农业大学

云南农业大学学报

CSTPCDCHSSCD
影响因子：0.49
ISSN：1004-390X
年,卷(期)：2024.39(7)