A mineral processing plant of one mine adopts"lead-sulfur mixing separation-asynchronous and other flotation"flow to recover lead-zinc minerals.The difference of floatability of each sulfide in the ore becomes larger along with deep ore deposition extraction,which leads to inadequate recovery of pyrite in lead-sulfur mixed flotation,a mass of pyrite floats during zinc flotation,it can affect concentration grade.It studied and developed a pyrite activator for the promotion of the flotability of pyrite according to the surface features of pyrite,to increase the flotability of pyrite,to solve the backward channeling problem of pyrite in lead-sulfur mixing separation operation.The on-site industrial test results show the recovery rate of the sulfur concentrate increased by 15.16%after the addition of the activator(ferrous sulfate).The green and efficient reagent system is adopted for this process,it can realize highly efficient comprehensive recovery of lead,zinc and sulfur.