基于谐波磁化响应半峰宽模型的非零场点磁性纳米粒子距离层析测量
Interlayer distance measurement of magnetic nanoparticles based on the harmonic magnetic response half-peak width model under non-zero field conditions
白石 1刘志尧 1盖伶柯 1李克文 1李天舒1
作者信息
- 1. 沈阳工业大学信息科学与工程学院 沈阳 110870
- 折叠
摘要
磁粒子成像技术是一种以生物功能化超顺磁性纳米粒子为示踪剂的全新人体功能层析成像技术,其通常必须构建基于梯度场的零磁场点/线并对其进行空间扫描以实现示踪剂定位,其空间分辨率正比于梯度场强度.而高强度梯度场需大体积电/永磁体构建,使其无法用于微创淋巴结术中定位.本研究在不使用梯度定位场条件下,提出基于朗之万函数和激励-磁化场空间分布计算的窄带磁纳米粒子深度定位理论,推导不同深度磁性纳米粒子产生的磁化响应与空间方位角的函数关系,建立半峰宽-距离检测与真实浓度解析模型,并进一步开发了磁粒子深度层析装置(即非梯度式一维磁粒子成像仪),体外实验测量结果表明其空间定位分辨率为 15 mm,误差5.21%,浓度模型还原误差为2.61%.对比已获批上市的欧洲Sentimag等静磁场磁粒子定位装置具有显著性能优势,可完全满足术中淋巴结定位等创新临床应用需求.
Abstract
Magnetic particle imaging(MPI)is an emerging human body functional layer scanning imaging technology that uses bio-functionalized superparamagnetic nanoparticles as tracers.It typically requires the construction of a field-free point/line based on a gradient field and spatial scanning of it to achieve tracer localization.Its spatial resolution is proportional to the gradient field strength.However,high-strength gradient fields need large-volume electro/permanent magnets to construct,making them unable to be used in clinical requirements like minimally invasive lymph node surgery for localization.This study,without using a gradient localization field,proposes a narrow-band magnetic nanoparticle depth positioning theory based on Langevin functions and calculations of the spatial distribution of excitation-magnetization fields.It derives the functional relationship among the magnetic responses produced by magnetic nanoparticles at different depths and the spatial azimuthal angle.A half-peak width-distance detection and true concentration analysis model is formulated.Furthermore,a magnetic particle depth layer scanner(a non-gradient one-dimensional magnetic particle imager)is developed.The vitro experimental measurements show that its spatial positioning resolution is 15 mm with an error of 5.21%,and the concentration model restoration error is 2.61%.Compared with the approved European Sentimag static magnetic field magnetic particle positioning device,it has significantly superior performance and can fully meet innovative clinical application requirements like intraoperative lymph node positioning.
关键词
磁粒子磁化响应/半峰宽/距离层析/浓度模型/前哨淋巴结Key words
magnetic particle magnetization response/half peak width/distance chromatography/concentration model/sentinel lymph node引用本文复制引用
基金项目
国家自然科学基金(62001313)
辽宁省科技重大重点项目(2021JH2/10300134)
辽宁省科技重大重点项目(2022JH1/10500004)
辽宁省教育厅重点项目(LJKZ0133)
沈阳市重点项目(22-321-32-09)
出版年
2024
NETL
NSTL
万方数据