首页|基于环形阵列的肌骨超声高分辨率断层成像

基于环形阵列的肌骨超声高分辨率断层成像

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超声断层成像技术因具有非侵入性、成本效益高、无辐射危害和设备便携等优势,正快速成为医学成像领域快速发展的焦点.然而,超声波在肌骨组织等声阻抗对比度较高的介质中传播时往往会产生复杂的散射现象,导致接收信号的波形畸变与幅度衰减,进而限制了超声断层成像的分辨率和精度.为此,采用环形阵列针对肌骨组织(包含数字体模和在体组织)进行了全矩阵数据采集,实现在大孔径条件下采集反射、透射、多次散射等多种模式的超声信号,然后运用多种算法重建目标截面的结构和参数图像.其中,延时叠加被用于对强反射界面的结构成像;渡越时间断层成像则有助于重建目标截面的低分辨率声速分布图像;而全波形反演则可在渡越时间断层成像的基础上,通过求解非线性反演问题生成更高分辨率的声速分布图像.通过仿真与实验测试,验证了结合渡越时间断层成像和多尺度频域全波形反演的方法,能够精确重建目标截面的不同组织成分,如皮肤、脂肪、肌肉和骨骼等,且分辨率达到0.4 mm.本文工作扩展了超声在医学成像领域的应用范围,对肌骨疾病的精确诊断具有重要的临床价值.
High resolution ultrasound computed tomography for the musculoskeletal system using a ring array
Ultrasound tomography technology is rapidly emerging as a focus of medical imaging due to its advantages of non-invasiveness,cost-effectiveness,lack of radiation harm,and portability.However,when ultrasound waves propagate in media with high acoustic impedance contrast such as the musculoskeletal system,complex scattering often occurs,leading to waveform distortion and amplitude attenuation of the received signals,thus limiting the resolution and accuracy of reconstruction.Therefore,we exploit a circular to collect full matrix data for musculoskeletal tissues(including numerical and in vivo examples),enabling collection of ultrasound signals in various modes including reflection,transmission,and multiple scatterings under full-aperture conditions.Subsequently,multiple algorithms are employed to reconstruct the qualitative and quantitative images of the target.Delay-and-sum technique is utilized to achieve structural imaging of strong reflection interfaces,while time-of-flight tomography imaging aids in reconstructing macro sound speed distribution images.Furthermore,full waveform inversion generates higher-resolution images of sound speed distribution by iteratively optimizing on top of time-of-flight tomography imaging results.Through numerical and experimental tests,the method combining time-of-flight tomography and multi-scale frequency-domain full waveform inversion is validated to precisely reconstruct different tissue components,such as skin,fat,muscle,and bones,achieving 0.4 mm resolution.The research expands the application scope of ultrasound in medical imaging holding significant clinical value for accurate diagnosis of musculoskeletal disorders.

ultrasound tomography scannermedical ultrasoundmusculoskeletal imagingfull waveform inversion

武小晴、李玉冰、苏畅、蒋乐康、林伟军

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中国科学院声学研究所 北京 100190

中国科学院大学 北京 100049

超声断层扫描仪 医学超声 肌骨成像 全波形反演

国家重点研发计划中国科学院声学研究所自主部署的目标导向项目

2023YFC2410803MBDX202113

2024

仪器仪表学报
中国仪器仪表学会

仪器仪表学报

CSTPCD北大核心
影响因子:2.372
ISSN:0254-3087
年,卷(期):2024.45(6)