注射用水储配系统的清洗和灭菌分析
Analysis of Cleaning and Sterilization of Injection Water Storage and Distribution System
张会民 1丁瑞辰 2唐兴隆 1曹帅1
作者信息
- 1. 兰州生物制品研究所有限责任公司,甘肃兰州 730000
- 2. 兰州生物技术开发有限公司,甘肃兰州 730000
- 折叠
摘要
针对注射用水储配系统中微生物和化学污染问题,本研究采用过热水和纯蒸汽两种高温灭菌技术对注射用水储配系统进行彻底灭菌.研究表明,过热水灭菌技术可以利用121℃高温高压水快速灭活储配系统中的各类微生物,达到无菌要求.该技术操作简单,灭菌效率更高,能耗更低.本研究为注射用水生产提供了一种先进的储配系统灭菌技术方案,有效解决微生物和化学污染问题,确保注射用水的质量安全.
Abstract
To address the issues of microbial and chemical contamination in the storage and distribution system of water for injection,this study employed two high-temperature sterilization techniques,namely superheated water and pure steam,to thoroughly sterilize the system.The research demonstrates that the superheated water sterilization technique can rapidly deactivate various microorganisms in the storage and distribution system using high-temperature and high-pressure water at 121°C,achieving sterility requirements.This technique is simple to operate,offers higher sterilization efficiency,and consumes less energy.This study provides an advanced sterilization technique for the storage and distribution system of water for injection,effectively addressing microbial and chemical contamination issues,and ensuring the quality and safety of water for injection.
关键词
微生物限度/注射用水储配/灭菌Key words
microbial limit/storage and distribution of water for injection/sterilization引用本文复制引用
出版年
2024
NETL
NSTL
万方数据