首页|In vivo anticancer activity of vanillin semicarbazone
In vivo anticancer activity of vanillin semicarbazone
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Objective:To evaluate the anticancer activity of vanillin semicarbazone (VSC) against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice. Methods:The compound VSC at three doses (5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight, enhancement of survival time as well as the changes in depleted hematological parameters. All such parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.). Results:Among the doses studied, 10 mg/kg (i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg (i.p.). The host toxic effects of VSC was found to be negligible. Conclusions: It can be concluded that VSC can therefore be considered as potent anticancer agent.
Anticancer activityEhrlich ascites carcinomaSchiff base
Shaikh M Mohsin Ali、M Abul Kalam Azad、Mele Jesmin、Shamim Ahsan、M Mijanur Rahman、Jahan Ara Khanam、M Nazrul Islam、Sha M Shahan Shahriar
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Department of Applied Chemistry and Chemical Engineering, University of Rajshahi
Department of Biochemistry and Molecular Biology, University of Rajshahi
Department of Chemistry, University of Chittagong
Department of Food Science&Technology, Chittagong Veterinary and Animal Science University
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This work was financially supported by University Grants Commission of Bangladesh
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