首页|The synergistic effect of honey and cinnamon against Streptococcus mutans bacteria

The synergistic effect of honey and cinnamon against Streptococcus mutans bacteria

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Objeetive:To investigate the effect of Iranian honey,cinnamon and their combination against Streptococcus mutans bacteria.Methods:Nine experimental solutions were examined in this study,including two types of honey (pasteurized and sterilized),two types of cinnamon extract (dissolved in distilled water or dimethyl sulfoxide) and five different mixtures of cinnamon in honey (prepared by admixing 1％-5％ w/w of cinnamon extract into 99％-95％ w/w of honey,respectively).Meanwhile,each of mentioned agent was considered as the first solution while it was diluted into seven serially two-fold dilutions (from 1∶2 to 1∶128 v/v).Therefore,eight diffcrent concentrations of each agent were tested.The antibacterial tests were performed through blood agar well diffusion method,and the minimum inhibitory concentration (MIC) was determined.Ultimately,the data were subjected to statistical analysis incorporating Two-way ANOVA and Bonferroni post hoc tests (α =0.01).Results:The highest zone of inhibition was recorded for the mixtures of honey and cinnamon while all the subgroups containing 95％-99％ v/v of honey were in the same range (P ＜ 0.01).The MIC for both honey solutions were obtained as 500 mg/mL whereas it was 50 mg/mL for both cinnamon solutions.Moreover,the MIC related to all honey/cinnamon mixtures were 200 mg/mL.Conclusions:A profound synergistic effect of honey and cinnamon was observed against Streptococcus mutans while there was no significant difference among extracts containing 99％-95％ v/v of honey admixing with 1％-5％ v/v of cinnamon,respectively.

Synergistic effectHoneyCinnamonStreptococcus mutans

Mohammad Bagher Rezvani、Mohammad Niakan、Mohammad Kamalinejad、Fateme Sadat Ahmadi、Faeze Hamze

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Operative Department,Shahed Dental School,Shahed University,Tehran,Iran

Microbiology Department,Shahed Medical School,Shahed University,Tehran,Iran

School of Pharmacy,Shahid Beheshti University of Medical Sciences,Tehran,Iran

Dental Research Center,Shahed Dental School,Shahed University,Tehran,Iran

Oral and Dental Disease Research Center,Kerman University of Medical Science,Kerman,Iran

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Supported by Dental Research Center of Shahed Dental School,Tehran,Iran

Grant No.41/41

2017

亚太热带生物医学杂志(英文版)

亚太热带生物医学杂志(英文版)

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年,卷(期)：2017.7(4)
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