Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer's disease

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外文摘要：Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl3)and D-galactose(D-GAL)-induced neurotoxicity in rats.Methods:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and liraglutide.AlCl3 and D-GAL were used to induce neurotoxicity.Behavioral tests,brain beta-amyloid protein,and oxidative stress biomarkers were evaluated.Results:The Morris water maze test indicated an enhanced memory in the combination group.Moreover,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain tissue.Neuronal inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were enhanced.Conclusions:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer's disease.

外文关键词：

Alzheimer's diseaseCognitive functionGlucagon-like peptide-1LiraglutideMemantine

作者：

Duaa M.Bakhshwin、Foziya W.Alhalabi、Mohamad Omar Barasheed、Ahmed M.Bakhshwin、Maha H.Jamal、Mohammed A.Bazuhair、Fatemah O.Kamel、Rania M.Magadmi、Zoheir A Damanhouri、Samar M.Alsaggaf

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作者单位：

Department of Clinical Pharmacology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia

Hera General Hospital,Makkah,Saudi Arabia

Department of Pathology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia

Department of Clinical Anatomy,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia

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出版年：

2024

DOI：

10.4103/apjtb.apjtb_937_23

亚太热带生物医学杂志(英文版)

ISSN：

年,卷(期)：2024.14(5)