首页|Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway
Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway
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Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver damage.Methods:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were evaluated.Additionally,a histopathological examination of liver tissues was performed.Results:Nicotine increased liver damage,inflammation,and oxidative stress.However,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory markers.Flavone(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed rats.Conclusions:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.
FlavoneNicotineLiverNrf2HO-1NF-κB
Nora A.Elsayed、Fatma SM Moawed、Esraa SA Ahmed、Ahmed Hammad、Omayma AR Abo-Zaid
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Biochemistry and Molecular Biology Department,Faculty of Vet.Med.Benha University,Benha city,Egypt
Health Radiation Research,National Center for Radiation Research and Technology,Egyptian Atomic Energy Authority,Cairo,Egypt
Radiation Biology Department,National Center for Radiation Research and Technology,Egyptian Atomic Energy Authority,Cairo,Egypt
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