首页|Asiaticoside ameliorates type 2 diabetes mellitus in rats by modulating carbohydrate metabolism and regulating insulin signaling

Asiaticoside ameliorates type 2 diabetes mellitus in rats by modulating carbohydrate metabolism and regulating insulin signaling

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Objective:To evaluate the effect of asiaticoside on streptozotocin(STZ)and nicotinamide(NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in rats.Methods:Asiaticoside(50 and 100 mg/kg body weight)was administered to STZ-NAD-induced diabetic rats for 45 days,and its effects on hyperglycaemic,carbohydrate metabolic,and insulin signaling pathway markers were examined.Results:Asiaticoside increased insulin production,lowered blood glucose levels,and enhanced glycolysis by improving hexokinase activity and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase activities.Abnormalities in glycogen metabolism were mitigated by increasing glycogen synthase activity and gluconeogenesis was decreased by decreasing glycogen phosphorylase activity.Furthermore,asiaticoside upregulated the mRNA expressions of IRS-1,IRS-2,and GLUT4 in STZ-NAD-induced diabetic rats and restored the beta cell morphology to normal.Conclusions:Asiaticoside has the potential to ameliorate type 2 diabetes by improving glycolysis,gluconeogenesis,and insulin signaling pathways.

AsiaticosideType 2 diabetes mellitusMetabolic disordersCarbohydrate metabolismInsulin signaling

B.Prathap、V.Satyanarayanan、K.Duraipandian、P.Subashree

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Department of Pharmacology,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India

Department of Pharmacology,SRM Medical College Hospital and Research Center,Kattankulathur 603211,Tamil Nadu,India

Department of Anatomy,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India

Department of Ophthalmology,Karpaga Vinayaga Institute of Medical Sciences and Research Center,Maduranthakam 603308,Tamil Nadu,India

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2024

亚太热带生物医学杂志(英文版)

亚太热带生物医学杂志(英文版)

ISSN:
年,卷(期):2024.14(9)